This study found that zero-dilation cSLO imaging had greater sensitivity for detection of DR lesion characteristics than traditional fundus imaging, with equivalent specificity. Imaging with the zero-dilation cSLO device can be performed relatively quickly and has the potential to improve efficiency and reduce appointment times for many patients, thereby improving patient care. Elimination of mydriasis and the associated waiting time and discomfort carries potential benefits for both patients and healthcare providers in terms of accessibility, acceptability and compliance with screening protocols. As primary care centers increasingly move towards greater use of digital screening techniques, with remote grading, the zero-dilation cSLO may facilitate screening of DR in these centers and thereby promote early diagnosis and treatment.

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